SOD1

Across TCGA pan-cancer cohorts, SOD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SOD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SOD1 RNA is repressed in tumor relative to normal tissue. In most cancer types SOD1 is over-expressed in tumor, although a few such as KICH and CHOL show the opposite, repressed pattern.

KICH, HNSC, and LUSC are the cancer types where SOD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.604	<.001	11	view →
HNSC	All	II,III,IV	+0.391	<.001	10	view →
LUSC	Female	All	+0.932	<.001	6	view →
BRCA	All	III,IV	+0.502	<.001	6	view →
CHOL	All	All	−1.530	<.001	5	view →
LUAD	All	All	+0.341	<.001	5	view →
KIRC	Male	All	−0.304	<.001	4	view →
ESCA	All	II,III,IV	+0.994	.009	2	view →
LIHC	Female	All	−0.510	.017	2	view →
KIRP	All	All	−0.490	<.001	2	view →
THCA	Male	All	−0.298	.011	2	view →
STAD	All	IV	+0.786	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SOD1–KICH

Open the KICH breakdown →