SOCS7

Across TCGA patient cohorts, SOCS7 mutation is significantly associated with the RNA expression of many other genes, with 514 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS7-associated genes across cancer lineages are RN7SKP286, TAS2R7, and LACRT. Each is linked with SOCS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS7-to-partner and partner-to-SOCS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by SOCS7-low versus SOCS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS7→partner) and Y-score (partner→SOCS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP286 →	+0.053	+4.253	<.001	.004	3	2
BLCA	TAS2R7 →	+0.035	+4.788	<.001	.006	3	1
BLCA	LACRT →	+0.989	+4.788	<.001	.006	3	1
BLCA	OR10G3 →	+0.041	+4.788	<.001	.006	3	1
BLCA	MRGPRX1 →	+0.964	+4.299	.001	.007	3	1
BLCA	LCE1D →	+0.324	+4.497	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 514 associations by consensus.

RN7SKP286 by SOCS7 expression — UCEC

Explore this box plot interactively →