SOCS7

Across TCGA pan-cancer cohorts, SOCS7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SOCS7’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SOCS7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOCS7 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

LIHC, COAD, and THCA are the cancer types where SOCS7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOCS7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.311	<.001	9	view →
COAD	Female	II,III,IV	+0.590	<.001	9	view →
THCA	All	II,III,IV	−0.731	<.001	8	view →
BRCA	Female	All	−0.480	<.001	6	view →
HNSC	All	All	+0.375	.004	6	view →
CHOL	Male	All	+2.706	<.001	5	view →
KICH	All	All	−0.743	<.001	5	view →
LUSC	All	All	+0.513	<.001	5	view →
READ	All	III,IV	+1.210	.021	4	view →
STAD	All	All	+0.636	.002	4	view →
LUAD	Female	All	−0.353	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SOCS7–LIHC

Open the LIHC breakdown →