SOCS7

Across TCGA cell cohorts, SOCS7 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SOCS7-associated genes across cancer lineages are MYF5, NAT8B, and ZNRF4. Each is linked with SOCS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS7-to-partner and partner-to-SOCS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by SOCS7-low versus SOCS7-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS7→partner) and Y-score (partner→SOCS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MYF5 →	+0.749	+5.321	<.001	.005	3	1
CNS	NAT8B →	+0.071	+4.981	<.001	.008	3	1
LARGE_INTESTINE	ZNRF4 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TSPY2 →	+0.041	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ODF4 →	+0.015	+4.022	<.001	.006	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MYF5 by SOCS7 expression — CNS

Explore this box plot interactively →