Across TCGA pan-cancer cohorts, SOCS5P4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SOCS5P4’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where SOCS5P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOCS5P4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
COAD, KIRP, and KIRC are the cancer types where SOCS5P4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOCS5P4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.