SOCS4

Across TCGA cell cohorts, SOCS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,395 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOCS4-associated GO terms across cancer lineages are Protein modification by small protein removal, Double-strand break repair, and Mitotic recombination. Each is linked with SOCS4 in more than 16 cancer types. Because this analysis shows association rather than direction, both SOCS4-to-partner and partner-to-SOCS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein modification by small protein removal grouped by SOCS4-low versus SOCS4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS4→partner) and Y-score (partner→SOCS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein modification by small protein removal →	+0.062	+0.922	<.001	.002	3	17
OESOPHAGUS	Double-strand break repair →	+0.072	+0.685	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Mitotic recombination →	+0.115	+0.993	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Centriole replication →	+0.121	+1.202	<.001	<.001	3	15
PANCREAS	Replication fork processing →	+0.095	+0.816	.001	<.001	3	15
KIDNEY	Heterochromatin organization →	+0.055	+0.952	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,395 associations by consensus.

Protein modification by small protein removal by SOCS4 expression — OESOPHAGUS

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