SOCS4

Across TCGA pan-cancer cohorts, SOCS4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SOCS4 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SOCS4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOCS4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

ACC, KIRC, and MESO are the cancer types where SOCS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.349	0.794	<.001	75	view →
KIRC	OS	Median	All	0.848	0.762	<.001	56	view →
MESO	OS	Median	III,IV	0.429	0.717	<.001	45	view →
KICH	DFS	Median	III,IV	0.318	0.901	.004	38	view →
LIHC	OS	Median	All	0.597	0.802	<.001	38	view →
UVM	DFS	Quartile	III,IV	0.234	0.900	.002	36	view →
LGG	OS	Quartile	All	0.687	0.964	<.001	20	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	18	view →
GBM	OS	Quartile	All	0.540	0.214	.020	13	view →
SKCM	DFS	Median	II,III,IV	0.271	0.184	.017	12	view →
HNSC	DFS	Quartile	IV	0.470	0.292	.015	9	view →
PRAD	DFS	Tertile	All	0.934	0.852	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SOCS4–ACC (DFS)

Open the ACC breakdown →