SOCS4

Across TCGA cell cohorts, SOCS4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SOCS4-associated genes across cancer lineages are MORC1, OR1E2, and DMRTB1. Each is linked with SOCS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS4-to-partner and partner-to-SOCS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MORC1 grouped by SOCS4-low versus SOCS4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS4→partner) and Y-score (partner→SOCS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MORC1 →	+0.072	+4.350	.006	.005	3	1
BLOOD_Lymphoma	OR1E2 →	+0.012	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	DMRTB1 →	+0.026	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	RIPPLY1 →	+0.038	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	PTH →	+0.017	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	WFDC13 →	+0.105	+4.927	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MORC1 by SOCS4 expression — BLOOD_Lymphoma

Explore this box plot interactively →