SOCS3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SOCS3 mutation is significantly associated with the RNA expression of many other genes, with 695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS3-associated genes across cancer lineages are ATF4P2, RNU7-194P, and RNA5SP394. Each is linked with SOCS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOCS3-to-partner and partner-to-SOCS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS3→partner) and Y-score (partner→SOCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATF4P2 →+0.039+2.599<.001.00932
SKCMRNU7-194P →+0.427+4.495<.001.00732
CESCRNA5SP394 →+0.263+3.760<.001.00432
CESCRN7SL248P →+0.105+5.584<.001.00132
COADRNU6-605P →+0.443+5.283<.001.00631
COADRNU6-987P →+0.803+5.357.001.00631
Each partner links to its Q-omics profile. Showing the 6 strongest of 695 associations by consensus.

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