SOCS2

Across TCGA patient cohorts, SOCS2 protein abundance is significantly associated with the protein abundance of many other proteins, with 10,381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOCS2-associated proteins across cancer lineages are NES_S842, DENND2A, and DCHS1. Each is linked with SOCS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOCS2-to-partner and partner-to-SOCS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOCS2 versus NES_S842 in UCEC, with a Pearson correlation of 0.48.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SOCS2→partner) and Y-score (partner→SOCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NES_S842 →	+0.775	+0.709	<.001	<.001	3	3
GBM	DENND2A →	+0.502	+0.942	<.001	<.001	3	3
UCEC	DCHS1 →	+0.320	+0.397	<.001	<.001	3	3
UCEC	TPM1_S174 →	+1.059	+0.764	<.001	<.001	3	2
UCEC	PRPF8 →	-0.205	-0.513	<.001	.001	3	2
UCEC	SYNPO2_S363 →	+1.287	+0.540	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,381 associations by consensus.

SOCS2 vs NES_S842 — UCEC

Explore this scatter interactively →