SOCS2-AS1

Across TCGA pan-cancer cohorts, SOCS2-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SOCS2-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SOCS2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOCS2-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

UVM, KIRC, and PAAD are the cancer types where SOCS2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.404	0.768	<.001	111	view →
KIRC	DFS	Quartile	IV	0.698	0.348	<.001	88	view →
PAAD	DFS	Median	All	0.421	0.160	<.001	85	view →
SKCM	OS	Tertile	All	0.815	0.914	.002	63	view →
MESO	OS	Median	All	0.277	0.496	<.001	57	view →
BLCA	OS	Median	IV	0.233	0.619	.002	54	view →
LGG	OS	Median	All	0.720	0.894	<.001	50	view →
LIHC	OS	Tertile	II,III,IV	0.559	0.267	.001	39	view →
OV	OS	Quartile	IV	0.800	0.432	.013	32	view →
KIRP	DFS	Median	All	0.956	0.864	.001	31	view →
UCS	DFS	Median	All	0.403	0.142	.006	26	view →
BRCA	OS	Quartile	All	0.979	0.936	.006	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SOCS2-AS1–UVM (DFS)

Open the UVM breakdown →