SOCS2-AS1

Across TCGA pan-cancer cohorts, SOCS2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SOCS2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SOCS2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SOCS2-AS1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where SOCS2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOCS2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.723	<.001	11	view →
KIRC	Female	II,III,IV	−0.646	<.001	11	view →
KIRP	Male	All	−1.205	<.001	10	view →
BLCA	Male	IV	−1.475	<.001	8	view →
THCA	Male	IV	−1.096	<.001	7	view →
LIHC	All	III,IV	−0.744	.001	7	view →
COAD	All	II,III,IV	−0.370	<.001	7	view →
UCEC	All	All	−1.657	<.001	6	view →
HNSC	All	II,III,IV	+0.336	.011	6	view →
LUAD	Female	III,IV	−0.562	<.001	5	view →
BRCA	Female	All	−0.827	<.001	4	view →
LUSC	Male	II,III,IV	−0.473	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SOCS2-AS1–KICH

Open the KICH breakdown →