SNX9

Across TCGA patient cohorts, SNX9 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX9-associated genes across cancer lineages are Notch1, C-Raf, and DJ-1. Each is linked with SNX9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX9-to-partner and partner-to-SNX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SNX9-low versus SNX9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX9→partner) and Y-score (partner→SNX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.156	+2.000	.004	.010	3	2
UCEC	C-Raf →	+0.146	+1.584	.009	.036	3	2
UCEC	DJ-1 →	+0.155	+2.820	.018	.035	3	2
UCEC	eEF2 →	+0.373	+2.321	.007	.034	3	1
UCEC	EGFR_pY1068 →	-0.254	-2.700	.010	.006	3	1
UCEC	eIF4E →	+0.244	+3.169	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Notch1 by SNX9 expression — UCEC

Explore this box plot interactively →