SNX8

Across TCGA cell cohorts, SNX8 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNX8-associated genes across cancer lineages are KERA, OR5B12, and MORN5. Each is linked with SNX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX8-to-partner and partner-to-SNX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KERA grouped by SNX8-low versus SNX8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX8→partner) and Y-score (partner→SNX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KERA →	+0.007	+3.381	<.001	.002	3	1
BLOOD_Leukemia	OR5B12 →	+0.034	+2.926	<.001	.009	3	1
BLOOD_Leukemia	MORN5 →	+0.147	+3.177	<.001	.004	3	1
BLOOD_Leukemia	UBE2QL1 →	+0.154	+4.270	.005	<.001	3	1
BLOOD_Leukemia	GSTT4 →	+0.143	+3.266	<.001	.003	3	1
LARGE_INTESTINE	IL17F →	+0.042	+2.444	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

KERA by SNX8 expression — BLOOD_Leukemia

Explore this box plot interactively →