SNX6

Across TCGA pan-cancer cohorts, SNX6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SNX6 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SNX6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNX6 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

COAD, LSCC, and GBM are the cancer types where SNX6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.877	1.000	.016	18	view →
LSCC	OS	Quartile	All	0.663	0.893	.008	7	view →
GBM	DFS	Quartile	All	0.691	0.886	.027	4	view →
UCEC	OS	Quartile	II,III,IV	0.352	1.000	.035	4	view →
PDAC	DFS	Median	II,III,IV	0.438	0.281	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SNX6–COAD (DFS)

Open the COAD breakdown →