SNX27

Across TCGA pan-cancer cohorts, SNX27 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SNX27 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNX27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNX27 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where SNX27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.525	0.763	.001	41	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.756	<.001	28	view →
PDAC	DFS	Quartile	All	0.948	0.638	.007	26	view →
LUAD	DFS	Median	III,IV	0.285	0.709	.026	5	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	2	view →
UCEC	DFS	Quartile	All	1.000	0.849	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SNX27–HNSC (DFS)

Open the HNSC breakdown →