SNX27

Across TCGA pan-cancer cohorts, SNX27 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SNX27’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNX27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNX27 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where SNX27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNX27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.805	<.001	11	view →
LIHC	Female	II,III,IV	+1.515	<.001	9	view →
BRCA	All	III,IV	+0.918	<.001	6	view →
LUAD	All	All	+0.335	.001	6	view →
KICH	Male	All	−0.790	<.001	4	view →
STAD	All	II,III,IV	+0.648	.008	4	view →
CHOL	All	All	+2.512	<.001	3	view →
PAAD	All	All	+0.302	.040	2	view →
BLCA	Male	IV	−1.012	.046	1	view →
ESCA	Female	All	+0.813	.034	1	view →
COAD	All	II,III,IV	+0.178	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SNX27–HNSC

Open the HNSC breakdown →