SNX27

Across TCGA patient cohorts, SNX27 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX27-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and eIF4E. Each is linked with SNX27 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX27-to-partner and partner-to-SNX27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SNX27-low versus SNX27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX27→partner) and Y-score (partner→SNX27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.314	-2.700	.005	.005	3	2
UCEC	EGFR_pY1068 →	-0.243	-2.070	.005	.001	3	1
UCEC	eIF4E →	+0.184	+2.070	.011	.001	3	1
UCEC	eIF4G →	+0.300	+3.459	.005	.005	3	1
UCEC	A-Raf_pS299 →	-0.134	-3.000	.001	<.001	3	1
UCEC	FoxM1 →	+0.190	+1.736	.034	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

INPP4B by SNX27 expression — UCEC

Explore this box plot interactively →