SNX27

Across TCGA cell cohorts, SNX27 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX27-associated genes across cancer lineages are TBR1, PROP1, and TEX46. Each is linked with SNX27 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX27-to-partner and partner-to-SNX27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBR1 grouped by SNX27-low versus SNX27-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX27→partner) and Y-score (partner→SNX27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBR1 →	+0.030	+3.555	.009	.003	3	1
LARGE_INTESTINE	PROP1 →	+0.027	+2.791	<.001	.005	3	1
LARGE_INTESTINE	TEX46 →	+0.148	+3.497	.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	RESP18 →	+0.030	+4.357	<.001	.006	3	1
LARGE_INTESTINE	MSH4 →	+0.331	+3.464	<.001	.004	2	1
LARGE_INTESTINE	ZCWPW2 →	+0.210	+3.285	.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TBR1 by SNX27 expression — LARGE_INTESTINE

Explore this box plot interactively →