SNX22

Across TCGA patient cohorts, SNX22 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX22-associated genes across cancer lineages are EGFR_pY1068, Notch1, and PAI-1. Each is linked with SNX22 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX22-to-partner and partner-to-SNX22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SNX22-low versus SNX22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX22→partner) and Y-score (partner→SNX22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.213	-1.584	.030	.036	3	2
UCEC	Notch1 →	+0.173	+3.472	.001	.002	3	2
UCEC	PAI-1 →	+0.296	+3.584	.028	.002	3	2
UCEC	14-3-3_beta →	-0.107	-2.432	.006	.018	3	1
UCEC	eIF4E →	+0.179	+2.000	.030	.010	3	1
UCEC	GATA6 →	-0.125	-1.577	.039	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by SNX22 expression — UCEC

Explore this box plot interactively →