SNX22

Across TCGA pan-cancer cohorts, SNX22 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SNX22 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SNX22 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNX22 expression acts as an unfavorable survival marker, although some lineages such as LUAD and THCA show a favorable association.

UVM, ACC, and KICH are the cancer types where SNX22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.411	0.813	<.001	136	view →
ACC	DFS	Tertile	All	0.235	0.780	<.001	89	view →
KICH	OS	Median	All	0.741	1.000	.001	64	view →
LUAD	OS	Quartile	All	0.753	0.580	<.001	47	view →
UCS	OS	Quartile	All	0.542	0.822	.017	42	view →
THCA	OS	Median	All	1.000	0.748	.002	37	view →
LGG	OS	Tertile	All	0.538	0.356	<.001	35	view →
BRCA	OS	Median	II,III,IV	0.939	0.884	.002	34	view →
MESO	OS	Quartile	All	0.715	0.403	.004	31	view →
SCLC	DFS	Median	All	0.606	0.366	.005	28	view →
KIRC	DFS	Median	All	0.565	0.678	.002	25	view →
SKCM	OS	Quartile	All	0.449	0.225	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SNX22–UVM (OS)

Open the UVM breakdown →