SNX21

Across TCGA pan-cancer cohorts, SNX21 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SNX21 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SNX21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNX21 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC and CCRCC are the cancer types where SNX21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.412	1.000	.040	8	view →
CCRCC	DFS	Quartile	All	0.953	0.674	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SNX21–UCEC (DFS)

Open the UCEC breakdown →