SNX21

Across TCGA pan-cancer cohorts, SNX21 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SNX21’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SNX21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNX21 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

LIHC, BLCA, and UCEC are the cancer types where SNX21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNX21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.986	<.001	9	view →
BLCA	All	III,IV	−0.844	<.001	8	view →
UCEC	All	III,IV	−1.688	<.001	6	view →
BRCA	All	II,III,IV	−1.000	<.001	6	view →
CHOL	All	All	+1.640	<.001	5	view →
KIRC	All	II,III,IV	−0.261	.005	5	view →
KIRP	Male	All	−0.710	.001	4	view →
LUSC	All	All	−0.515	<.001	4	view →
HNSC	Male	IV	−0.679	.008	2	view →
PAAD	All	All	+0.597	.023	2	view →
PRAD	All	All	−0.420	<.001	2	view →
THCA	Male	II,III,IV	−0.252	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SNX21–LIHC

Open the LIHC breakdown →