SNX21

Across TCGA patient cohorts, SNX21 mutation is significantly associated with the RNA expression of many other genes, with 352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX21-associated genes across cancer lineages are MIR3927, RNU6-1210P, and RNU6-1050P. Each is linked with SNX21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX21-to-partner and partner-to-SNX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3927 grouped by SNX21-low versus SNX21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX21→partner) and Y-score (partner→SNX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3927 →	+0.130	+4.010	<.001	.007	3	2
SKCM	RNU6-1210P →	+0.310	+5.797	<.001	.001	3	2
BLCA	RNU6-1050P →	+0.662	+4.363	<.001	.007	3	1
BLCA	NPM1P4 →	+0.063	+4.533	<.001	.005	3	1
BLCA	RPL31P16 →	+0.121	+4.680	.006	.003	3	1
BLCA	SUPT4H1P2 →	+0.154	+4.331	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 352 associations by consensus.

MIR3927 by SNX21 expression — UCEC

Explore this box plot interactively →