SNX21

Across TCGA cell cohorts, SNX21 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNX21-associated genes across cancer lineages are LCN9, RLN1, and NDP. Each is linked with SNX21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX21-to-partner and partner-to-SNX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN9 grouped by SNX21-low versus SNX21-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX21→partner) and Y-score (partner→SNX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LCN9 →	+0.072	+5.169	<.001	.005	3	1
BLOOD_Leukemia	RLN1 →	+0.509	+3.459	<.001	.007	3	1
BLOOD_Leukemia	NDP →	+0.032	+3.177	<.001	.004	3	1
BLOOD_Leukemia	OR11H1 →	+0.044	+3.786	<.001	.002	3	1
BLOOD_Leukemia	TRPC3 →	+1.151	+3.523	<.001	.005	3	1
BLOOD_Leukemia	SLC17A4 →	+0.053	+2.982	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

LCN9 by SNX21 expression — BREAST

Explore this box plot interactively →