SNX21

Across TCGA cell cohorts, SNX21 mutation is significantly associated with the mutation status of many other genes, with 3,696 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX21-associated genes across cancer lineages are CNOT3, COL16A1, and NGEF. Each is linked with SNX21 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNX21-to-partner and partner-to-SNX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNOT3 grouped by SNX21-low versus SNX21-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX21→partner) and Y-score (partner→SNX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CNOT3 →	+4.429	+5.247	.005	.005	1	3
LARGE_INTESTINE	COL16A1 →	+2.284	+3.925	.005	.005	1	3
LARGE_INTESTINE	NGEF →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	APBB1IP →	+3.159	+4.632	<.001	<.001	1	3
BLOOD_Leukemia	KLK14 →	+5.050	+4.000	.008	.008	1	3
LARGE_INTESTINE	HEATR5B →	+2.284	+3.925	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,696 associations by consensus.

CNOT3 by SNX21 expression — BLOOD_Lymphoma

Explore this box plot interactively →