Across TCGA patient cohorts, SNX2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX2-associated genes across cancer lineages are FOXO3a, PREX1, and 14-3-3_beta. Each is linked with SNX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX2-to-partner and partner-to-SNX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX2→partner) and Y-score (partner→SNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FOXO3a →	+0.183	+3.008	.016	.019	3	1
COAD	PREX1 →	+0.238	+2.840	.027	.033	3	1
UCEC	14-3-3_beta →	-0.069	-2.195	.032	.009	3	1
UCEC	eEF2 →	+0.341	+3.700	.002	.001	3	1
UCEC	ERK2 →	+0.195	+2.378	.001	<.001	3	1
UCEC	GAPDH →	+0.412	+2.000	.016	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

SNX2 survival (RNA) · tumor vs normal (RNA) · all SNX2 data types