SNX15

Across TCGA pan-cancer cohorts, SNX15 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SNX15 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNX15 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SNX15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, KICH, and CESC are the cancer types where SNX15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.755	0.619	.001	82	view →
KICH	DFS	Tertile	II,III,IV	0.687	1.000	.006	52	view →
CESC	DFS	Quartile	All	0.765	0.918	.001	46	view →
UCS	DFS	Median	IV	0.952	0.367	.001	38	view →
BLCA	OS	Median	II,III,IV	0.491	0.352	.004	37	view →
UCEC	DFS	Median	All	0.546	0.734	<.001	36	view →
LIHC	DFS	Tertile	All	0.447	0.591	.002	29	view →
LGG	DFS	Median	All	0.786	0.875	<.001	24	view →
BRCA	OS	Quartile	III,IV	0.929	0.734	.001	23	view →
KIRC	DFS	Tertile	II,III,IV	0.372	0.615	.011	22	view →
PRAD	DFS	Tertile	All	0.671	0.809	<.001	22	view →
ESCA	DFS	Quartile	III,IV	0.612	0.366	.004	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SNX15–HNSC (OS)

Open the HNSC breakdown →