SNTB1

Across TCGA patient cohorts, SNTB1 mutation is significantly associated with the RNA expression of many other genes, with 2,565 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNTB1-associated genes across cancer lineages are NANS, PPP1R1AP2, and BUB3. Each is linked with SNTB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNTB1-to-partner and partner-to-SNTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NANS grouped by SNTB1-low versus SNTB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNTB1→partner) and Y-score (partner→SNTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NANS →	+0.536	+2.513	.001	.001	3	3
BLCA	PPP1R1AP2 →	+0.064	+7.640	<.001	.009	3	2
UCEC	BUB3 →	+0.462	+3.625	.001	.001	3	2
UCEC	TEDC2 →	+0.633	+3.724	.001	<.001	2	3
UCEC	CHCHD4 →	+0.454	+2.523	<.001	.001	3	2
UCEC	COX18 →	+0.669	+3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,565 associations by consensus.

NANS by SNTB1 expression — UCEC

Explore this box plot interactively →