SNTB1

Across TCGA pan-cancer cohorts, SNTB1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SNTB1 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SNTB1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNTB1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

UVM, KIRP, and LUAD are the cancer types where SNTB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.278	0.751	<.001	93	view →
KIRP	DFS	Tertile	All	0.776	0.948	<.001	77	view →
LUAD	DFS	Quartile	III,IV	0.647	0.308	<.001	52	view →
COAD	DFS	Quartile	All	0.389	0.583	.003	38	view →
SARC	DFS	Tertile	All	0.211	0.461	<.001	31	view →
BLCA	DFS	Quartile	IV	0.100	0.385	.002	29	view →
SKCM	OS	Tertile	All	0.389	0.207	<.001	24	view →
HNSC	DFS	Tertile	IV	0.429	0.229	.008	23	view →
MESO	DFS	Median	All	0.480	0.297	.014	21	view →
KIRC	DFS	Quartile	All	0.803	0.548	.015	16	view →
SCLC	OS	Median	IV	0.219	0.729	.003	15	view →
LIHC	DFS	Quartile	III,IV	0.172	0.595	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SNTB1–UVM (DFS)

Open the UVM breakdown →