SNTB1

Across TCGA cell cohorts, SNTB1 mutation is significantly associated with the drug of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNTB1-associated genes across cancer lineages are Sabutoclax, TL-2-105, and FR-180204. Each is linked with SNTB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNTB1-to-partner and partner-to-SNTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sabutoclax grouped by SNTB1-low versus SNTB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNTB1→partner) and Y-score (partner→SNTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sabutoclax →	+0.434	+2.769	.041	.040	3	1
LARGE_INTESTINE	TL-2-105 →	+0.522	+2.652	.007	.045	3	1
LARGE_INTESTINE	FR-180204 →	+0.378	+2.652	.022	.045	3	1
LARGE_INTESTINE	SU11274 →	+0.518	+2.652	.012	.045	3	1
LARGE_INTESTINE	Masitinib →	+0.452	+2.652	.035	.045	3	1
LARGE_INTESTINE	Fedratinib →	+0.554	+2.652	.034	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Sabutoclax by SNTB1 expression — LARGE_INTESTINE

Explore this box plot interactively →