SNRPN

Across TCGA patient cohorts, SNRPN mutation is significantly associated with the RNA expression of many other genes, with 4,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRPN-associated genes across cancer lineages are MTFMT, HAUS2, and ZNF746. Each is linked with SNRPN in more than 3 cancer types. Because this analysis shows association rather than direction, both SNRPN-to-partner and partner-to-SNRPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFMT grouped by SNRPN-low versus SNRPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRPN→partner) and Y-score (partner→SNRPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTFMT →	+0.459	+2.459	<.001	<.001	3	4
UCEC	HAUS2 →	+0.721	+2.459	<.001	<.001	3	4
UCEC	ZNF746 →	+0.331	+2.032	.004	.005	3	4
UCEC	PRPF40A →	+0.577	+2.480	<.001	<.001	3	4
UCEC	GAN →	+0.320	+3.711	.006	<.001	3	4
UCEC	RAD51 →	+0.868	+2.470	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,084 associations by consensus.

MTFMT by SNRPN expression — UCEC

Explore this box plot interactively →