SNRPN

Across TCGA pan-cancer cohorts, SNRPN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SNRPN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SNRPN RNA is repressed in tumor relative to normal tissue. In most cancer types SNRPN is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where SNRPN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRPN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.226	<.001	12	view →
THCA	All	IV	−0.985	<.001	11	view →
KICH	Male	All	−2.017	<.001	10	view →
LUSC	All	III,IV	−1.606	<.001	8	view →
STAD	All	All	−1.206	<.001	8	view →
KIRP	All	All	−1.027	<.001	7	view →
BLCA	All	All	−1.331	.002	6	view →
HNSC	Male	All	−1.107	<.001	6	view →
COAD	All	II,III,IV	−1.056	<.001	6	view →
LUAD	All	All	−0.602	<.001	6	view →
LIHC	All	All	+0.583	.002	4	view →
BRCA	Female	II,III,IV	−0.537	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SNRPN–KIRC

Open the KIRC breakdown →