SNRPN

Across TCGA patient cohorts, SNRPN mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRPN-associated genes across cancer lineages are PRDX1, p21, and PARP_cleaved. Each is linked with SNRPN in more than 2 cancer types. Because this analysis shows association rather than direction, both SNRPN-to-partner and partner-to-SNRPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by SNRPN-low versus SNRPN-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRPN→partner) and Y-score (partner→SNRPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PRDX1 →	+0.269	+2.331	.031	.019	3	3
LUSC	p21 →	-0.342	-2.312	.036	.035	3	2
LUSC	PARP_cleaved →	+0.473	+2.825	.010	.033	3	2
UCEC	p90 RSK →	+0.160	+1.691	.029	.014	3	2
UCEC	P-Cadherin →	-0.182	-2.074	<.001	.005	3	2
UCEC	STAT3_pY705 →	-0.261	-1.690	.009	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

PRDX1 by SNRPN expression — LUSC

Explore this box plot interactively →