SNRPEP11

Across TCGA pan-cancer cohorts, SNRPEP11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SNRPEP11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNRPEP11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNRPEP11 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where SNRPEP11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRPEP11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.615	<.001	8	view →
KIRC	All	II,III,IV	+0.480	<.001	8	view →
LIHC	Male	All	+0.713	<.001	6	view →
BRCA	All	All	+0.390	<.001	6	view →
LUSC	Male	All	+0.680	<.001	5	view →
LUAD	Male	All	+0.877	<.001	4	view →
KICH	All	All	−0.626	.001	4	view →
BLCA	All	III,IV	+0.578	.031	3	view →
CHOL	All	All	+0.958	.002	2	view →
COAD	Female	All	−0.606	.019	2	view →
ESCA	All	II,III,IV	+0.410	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SNRPEP11–HNSC

Open the HNSC breakdown →