SNRPE

Across TCGA patient cohorts, SNRPE mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRPE-associated genes across cancer lineages are IGFBP2, Ku80, and Tuberin. Each is linked with SNRPE in more than 1 cancer types. Because this analysis shows association rather than direction, both SNRPE-to-partner and partner-to-SNRPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SNRPE-low versus SNRPE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRPE→partner) and Y-score (partner→SNRPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.759	-3.321	.025	.010	3	1
UCEC	Ku80 →	+0.253	+2.183	.041	.035	3	1
UCEC	Tuberin →	+0.369	+2.817	.009	.036	3	1
UCEC	Caspase-8 →	-0.344	-2.973	.008	.035	3	1
UCEC	4E-BP1 →	+0.311	+2.837	.028	.035	3	1
UCEC	C-Raf →	+0.221	+3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IGFBP2 by SNRPE expression — UCEC

Explore this box plot interactively →