SNRPE

Across TCGA pan-cancer cohorts, SNRPE RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SNRPE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNRPE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNRPE is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where SNRPE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRPE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.282	<.001	12	view →
KIRC	Male	IV	+0.704	<.001	12	view →
LUAD	Male	II,III,IV	+1.266	<.001	11	view →
COAD	Female	II,III,IV	+1.154	<.001	11	view →
BLCA	Female	III,IV	+1.075	<.001	11	view →
LIHC	Male	II,III,IV	+1.878	<.001	9	view →
LUSC	Female	All	+1.295	<.001	8	view →
STAD	Female	All	+0.975	<.001	8	view →
KIRP	All	II,III,IV	+0.682	<.001	7	view →
BRCA	All	III,IV	+1.245	<.001	6	view →
CHOL	Male	All	+2.994	<.001	5	view →
KICH	Female	All	−1.202	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SNRPE–HNSC

Open the HNSC breakdown →