SNRPC

Across TCGA patient cohorts, SNRPC mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRPC-associated genes across cancer lineages are MIR6851, OR4F21, and RNU6-198P. Each is linked with SNRPC in more than 1 cancer types. Because this analysis shows association rather than direction, both SNRPC-to-partner and partner-to-SNRPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6851 grouped by SNRPC-low versus SNRPC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRPC→partner) and Y-score (partner→SNRPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6851 →	+0.673	+2.839	<.001	.004	3	1
SKCM	OR4F21 →	+0.093	+5.037	<.001	.009	3	1
SKCM	RNU6-198P →	+0.443	+6.624	<.001	.001	3	1
SKCM	MIR520E →	+0.683	+7.485	<.001	<.001	3	1
SKCM	RNU6-482P →	+0.483	+5.159	<.001	.007	3	1
SKCM	RNU11-6P →	+0.416	+5.594	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MIR6851 by SNRPC expression — UCEC

Explore this box plot interactively →