SNRPC

Across TCGA pan-cancer cohorts, SNRPC RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SNRPC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNRPC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNRPC is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where SNRPC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNRPC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.892	<.001	12	view →
KIRC	Female	IV	+0.716	<.001	12	view →
COAD	Female	II,III,IV	+0.908	<.001	11	view →
LIHC	Male	II,III,IV	+1.616	<.001	9	view →
STAD	Female	All	+1.127	<.001	9	view →
LUAD	Female	III,IV	+0.807	<.001	9	view →
BLCA	All	All	+0.719	<.001	9	view →
KIRP	All	II,III,IV	+0.629	<.001	9	view →
KICH	Female	II,III,IV	−1.468	<.001	8	view →
LUSC	Female	II,III,IV	+0.934	<.001	6	view →
BRCA	All	III,IV	+0.739	<.001	6	view →
UCEC	All	All	+0.494	.006	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SNRPC–HNSC

Open the HNSC breakdown →