SNRPA

Across TCGA pan-cancer cohorts, SNRPA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SNRPA data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNRPA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNRPA expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where SNRPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.694	0.932	.002	25	view →
LUAD	DFS	Median	All	0.961	0.668	.009	6	view →
GBM	OS	Quartile	All	0.580	0.334	.028	4	view →
LSCC	OS	Median	II,III,IV	0.954	0.776	.012	4	view →
CCRCC	DFS	Tertile	All	0.856	0.513	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SNRPA–HNSC (DFS)

Open the HNSC breakdown →