SNRPA

Across TCGA patient cohorts, SNRPA mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRPA-associated genes across cancer lineages are SLF1, RNU6-1205P, and RNU6-763P. Each is linked with SNRPA in more than 1 cancer types. Because this analysis shows association rather than direction, both SNRPA-to-partner and partner-to-SNRPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLF1 grouped by SNRPA-low versus SNRPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRPA→partner) and Y-score (partner→SNRPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLF1 →	+0.582	+3.459	.003	.005	3	2
SKCM	RNU6-1205P →	+0.408	+3.780	<.001	<.001	3	2
SKCM	RNU6-763P →	+0.183	+4.900	<.001	.002	3	2
UCEC	RNA5SP205 →	+0.310	+3.267	<.001	.005	3	2
UCEC	RNA5SP176 →	+0.477	+3.923	<.001	.009	3	2
UCEC	RNA5SP113 →	+0.514	+3.641	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

SLF1 by SNRPA expression — UCEC

Explore this box plot interactively →