SNRPA

Across TCGA patient cohorts, SNRPA mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRPA-associated genes across cancer lineages are GAPDH, eIF4E, and JNK_pT183_Y185. Each is linked with SNRPA in more than 1 cancer types. Because this analysis shows association rather than direction, both SNRPA-to-partner and partner-to-SNRPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SNRPA-low versus SNRPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRPA→partner) and Y-score (partner→SNRPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.601	+3.000	.032	.036	3	2
UCEC	eIF4E →	+0.242	+3.321	.028	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-3.000	.032	.036	3	1
UCEC	JNK2 →	+0.252	+3.321	.015	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.873	+3.019	.004	.019	3	1
UCEC	ERK2 →	+0.200	+3.000	.047	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GAPDH by SNRPA expression — UCEC

Explore this box plot interactively →