SNRNP40

Across TCGA patient cohorts, SNRNP40 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRNP40-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and Ku80. Each is linked with SNRNP40 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNRNP40-to-partner and partner-to-SNRNP40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SNRNP40-low versus SNRNP40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRNP40→partner) and Y-score (partner→SNRNP40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+2.700	.037	.006	3	2
UCEC	14-3-3_beta →	-0.099	-3.143	.028	.018	3	1
UCEC	Ku80 →	+0.279	+2.013	.008	.018	3	1
UCEC	Notch1 →	+0.199	+1.884	.001	.030	3	1
UCEC	p62 Lck ligand →	+0.364	+2.179	.013	.034	3	1
UCEC	Rad50 →	-0.255	-3.807	.019	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by SNRNP40 expression — UCEC

Explore this box plot interactively →