SNRK

Across TCGA patient cohorts, SNRK mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNRK-associated genes across cancer lineages are ATM, FASN, and MEK1. Each is linked with SNRK in more than 2 cancer types. Because this analysis shows association rather than direction, both SNRK-to-partner and partner-to-SNRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SNRK-low versus SNRK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNRK→partner) and Y-score (partner→SNRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.416	-1.415	.003	.010	3	3
COAD	FASN →	+0.515	+2.815	.016	.036	2	3
UCEC	MEK1 →	+0.410	+1.893	<.001	<.001	3	2
UCEC	eEF2 →	+0.259	+1.700	.019	.040	3	2
UCEC	GSK3-a-b →	+0.094	+2.115	.024	.016	3	2
UCEC	Rad50 →	-0.254	-1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by SNRK expression — UCEC

Explore this box plot interactively →