SNPH

Across TCGA cell cohorts, SNPH mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNPH-associated genes across cancer lineages are ADAM2, OR11G2, and SCRT2. Each is linked with SNPH in more than 1 cancer types. Because this analysis shows association rather than direction, both SNPH-to-partner and partner-to-SNPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by SNPH-low versus SNPH-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNPH→partner) and Y-score (partner→SNPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADAM2 →	+0.005	+5.022	<.001	.002	3	1
SKIN	OR11G2 →	+0.011	+4.930	.002	.001	3	1
SKIN	SCRT2 →	+0.006	+4.095	<.001	.009	3	1
BLOOD_Leukemia	APCS →	+0.049	+3.201	<.001	.005	3	1
BLOOD_Leukemia	RNASE7 →	+0.030	+2.842	.009	.006	3	1
BLOOD_Leukemia	TBC1D3C →	+0.935	+3.900	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ADAM2 by SNPH expression — SKIN

Explore this box plot interactively →