SNPH

Across TCGA pan-cancer cohorts, SNPH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SNPH’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SNPH RNA is repressed in tumor relative to normal tissue. In most cancer types SNPH is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and LIHC are the cancer types where SNPH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNPH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.072	<.001	8	view →
THCA	Male	All	−0.962	<.001	8	view →
LIHC	All	II,III,IV	+0.482	<.001	8	view →
UCEC	All	All	−1.540	<.001	6	view →
COAD	Male	All	−0.717	.004	6	view →
KIRC	All	II,III,IV	−0.382	.002	6	view →
KICH	All	All	−0.606	.008	4	view →
READ	All	All	−1.155	.007	3	view →
CHOL	All	All	+1.148	.004	3	view →
LUSC	Male	All	−0.470	<.001	3	view →
PRAD	All	All	−0.859	<.001	2	view →
LUAD	All	All	−0.244	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SNPH–BLCA

Open the BLCA breakdown →