Across TCGA pan-cancer cohorts, SNORD59A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNORD59A’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SNORD59A RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD59A is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, CHOL, and COAD are the cancer types where SNORD59A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD59A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.818	<.001	6	view →
CHOL	All	All	+0.832	.002	4	view →
COAD	Female	All	+0.790	.020	2	view →
KIRC	Male	IV	+0.491	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SNORD59A RNA expression & survival · all SNORD59A data types