small nucleolar RNA, C/D box 59AGenealiases: RNU59 · U59
Q-omics provides the consensus-scored SNORD59A profile across patient tissues and cancer cell-line models. SNORD59A expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, SNORD59A is differentially expressed in 4, with the highest sampling consensus in BRCA. Additionally, SNORD59A RNA expression shows 16,022 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight BLCA, BRCA, and UVM as cancer lineages where SNORD59A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SNORD59A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SNORD59A survival associations across molecular data types. SNORD59A RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SNORD59A RNA expression–survival associations across cancer types. High SNORD59A expression shows unfavorable associations in KICH, THCA, PCPG, LGG and UVM, but favorable associations in BLCA. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify BLCA as the clearest survival context for SNORD59A RNA expression.
This table summarizes SNORD59A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for SNORD59A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SNORD59A shows lower tumor expression in BRCA and higher tumor expression in CHOL, COAD and KIRC. The BRCA box plot shows higher SNORD59A RNA expression in normal versus tumor tissue (log2 FC = −0.818, t-test p < 0.001).
This table shows molecular features associated with SNORD59A in patient tissues and cancer cell lines. In patient samples, SNORD59A shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
