SNORD53B

Across TCGA pan-cancer cohorts, SNORD53B RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SNORD53B data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher SNORD53B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD53B expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

CHOL, UCEC, and PAAD are the cancer types where SNORD53B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Median	III,IV	0.286	1.000	.008	31	view →
UCEC	DFS	Quartile	All	0.517	0.694	.004	30	view →
PAAD	OS	Quartile	All	0.459	0.624	.013	21	view →
DLBC	DFS	Median	All	0.571	1.000	.005	20	view →
PCPG	DFS	Quartile	All	0.338	0.844	.016	17	view →
UVM	DFS	Tertile	III,IV	0.331	0.628	.024	16	view →
KIRC	DFS	Median	All	0.556	0.688	.008	15	view →
LIHC	DFS	Tertile	All	0.444	0.585	.025	12	view →
HNSC	OS	Tertile	All	0.289	0.490	.008	11	view →
THCA	DFS	Quartile	III,IV	0.804	0.933	.004	11	view →
ESCA	DFS	Tertile	II,III,IV	0.392	0.601	.009	9	view →
CESC	OS	Tertile	All	0.461	0.660	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SNORD53B–CHOL (OS)

Open the CHOL breakdown →