SNORD53B

Across TCGA pan-cancer cohorts, SNORD53B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SNORD53B’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where SNORD53B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD53B is over-expressed in tumor.

STAD, BLCA, and LUSC are the cancer types where SNORD53B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD53B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.784	.001	6	view →
BLCA	All	All	+0.711	.010	6	view →
LUSC	All	All	+0.722	<.001	5	view →
COAD	All	All	+0.608	<.001	5	view →
HNSC	All	III,IV	+0.472	.007	5	view →
KIRC	All	All	+0.331	.001	4	view →
LUAD	All	All	+0.616	<.001	3	view →
READ	All	II,III,IV	+1.557	.021	2	view →
CHOL	All	All	+1.082	.003	2	view →
ESCA	Female	All	+0.923	.018	1	view →
KIRP	Male	All	+0.230	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SNORD53B–STAD

Open the STAD breakdown →